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目的观察不同剂量甘露醇在治疗急性脑出血时对肾脏的损害。方法将120例急性脑出血患者随机分为半量组、全量组各60例。半量组用甘露醇125ml、全量组用甘露醇250ml进行脱水降颅压治疗,治疗前及治疗后第3、5、7天监测尿常规、血尿素氮、血肌酐,分析甘露醇对肾脏的损害。结果两组患者治疗后疗效差异无统计学意义,而对肾脏的损害在治疗后第5天差异有统计学意义(P<0.05),第7天差异有统计学意义(P<0.01)。结论不同剂量甘露醇治疗脑出血时疗效差异无统计学意义,小剂量、短期使用对肾功能损害小。
Objective To observe the different doses of mannitol in the treatment of acute intracerebral hemorrhage kidney damage. Methods A total of 120 patients with acute cerebral hemorrhage were randomly divided into half dose group and full dose group. Half dose group with mannitol 125ml, the whole group with mannitol 250ml for dehydration intracranial pressure treatment before treatment and 3,5,7 days after treatment to monitor urinary sodium, blood urea nitrogen, serum creatinine, analysis of mannitol damage to the kidneys . Results There was no significant difference in curative effect between the two groups (P <0.05), while the difference between the two groups on the fifth day after treatment was statistically significant (P <0.05). There was a significant difference on the seventh day (P <0.01). Conclusion Different doses of mannitol in the treatment of intracerebral hemorrhage difference was not statistically significant, low-dose, short-term use of renal damage.