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目的探讨肉毒中毒引发呼吸衰竭的临床表现以及治疗效果。方法选取我院2008年—2015年收治的肉毒中毒引发呼吸衰竭的患者22例进行回顾性分析。结果 22例患者均有头昏、视物模糊和四肢无力症状,而呕吐症状在患者中出现的比例最低(54.55%);机械通气48 h以及撤机后,患者呼吸频率、PH、Pa CO_2、Sa O_2等呼吸指标有明显好转,差异有统计学意义(P<0.05);经过治疗,所有患者均痊愈出院。结论肉毒中毒引发呼吸衰竭的患者,应尽早使用呼吸机改善患者呼吸状况,并行支持治疗、抗肉毒血清治疗、抗生素防治感染和营养补充等。
Objective To investigate the clinical manifestations and therapeutic effects of botulism induced respiratory failure. Methods 22 cases of respiratory failure caused by botulism in our hospital from 2008 to 2015 were retrospectively analyzed. Results All the 22 patients had dizziness, blurred vision and weakness of the extremities, while vomiting was the lowest in patients (54.55%). After mechanical ventilation for 48 h and after weaning, the respiratory rate, PH, Pa CO 2, Sa O_2 and other respiratory indicators improved significantly, the difference was statistically significant (P <0.05); after treatment, all patients were cured and discharged. Conclusion Patients with respiratory failure caused by botulism should use ventilator as soon as possible to improve respiratory status, supportive treatment, anti-botulism serum treatment, antibiotic infection control and nutritional supplementation.