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香芪口服液是哈尔滨医科大学研制的新型制剂,具有抗病毒,抗肿瘤和免疫调节作用。现将其毒理学研究结果报告于下:1 材料 香芪口服液由哈尔滨医科大学新生物技术公司生产。动物系黑龙江省肿瘤研究所提供的昆明系小鼠。菌种由美国加利福尼亚大学Ames实验室引进,为鼠伤寒沙门氏菌TA_(97)、TA_(98)、A_(100)、TA_(102)四株,经五项特性鉴定均符合标准要求。S_(-9)肝微粒酶,由本室新近制备,经用已知突变物鉴定,酶活性良好。2 方法 小鼠经口LD_(50)试验:按霍恩氏(Horn)法进行。Ames试验:按国内规定的统一方法试验。小鼠骨髓嗜多染红细胞微核试验:以千分率表示。小鼠睾丸染色体畸变试验,记录统计畸变细胞数,计算畸变率。
Xiangxi Oral Liquid is a new type of preparation developed by Harbin Medical University. It has anti-virus, anti-tumor and immunomodulatory effects. The results of its toxicology study are reported below: 1 Materials Xiangxi Oral Liquid was produced by Harbin Medical University New Biotechnology Company. Animals Kunming mice provided by Heilongjiang Cancer Institute. The strains were introduced by Ames Laboratories of the University of California, USA. They were four strains of Salmonella typhimurium TA_(97), TA_(98), A_(100), and TA_(102). The five characteristics were all met the standard requirements. S_ (-9) hepatic microsomal enzymes, newly prepared by our laboratory, were identified by known mutations and had good enzyme activity. 2 Methods Mouse oral LD_(50) test: performed according to the Horn method. Ames test: Test according to the uniform method prescribed by the country. Micronucleus test of polychromatic erythrocytes in mouse bone marrow: expressed in parts per thousand. Testicular chromosome aberration test in mice. The number of distorted cells was recorded and the rate of distortion was calculated.