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目的 研究探索神经元内谷氨酸脱羧酶 ( GAD)和 γ-氨基丁酸转氨酶 ( GABA-T)的活性与癫痫发病的关系。方法 用致痫剂马桑内酯 ( CL)和抗痫剂苯妥因钠 ( PHT)处理大鼠培养海马神经元 ,用液体闪烁计数仪、紫外分光光度计检测培养神经元内 GAD和 GABA-T的活性。结果 与对照组比较 ,CL致痫组培养神经元内GAD活性和 GABA-T的活性显著增高 ;运用抗痫剂 PHT处理致痫神经元后 ,与 CL致痫组比较 ,神经元内GABA-T活性显著降低 ;与对照组比较差异不显著。结论 在癫痫发病中 ,痫性神经元 GAD和 GABA-T活性增高。
Objective To explore the relationship between the activity of glutamate decarboxylase (GAD) and γ-aminobutyrate aminotransferase (GABA-T) and the incidence of epilepsy in neurons. Methods The hippocampal neurons were cultured with epileptogenic agents such as CL and CLT, and the levels of GAD and GABA-1 in cultured neurons were measured by liquid scintillation counter and UV spectrophotometer. T activity. Results Compared with the control group, GAD activity and GABA-T activity were significantly increased in the neurons of CL-induced epileptogenic group. Compared with CL-induced epileptic neurons, GABA-T Activity was significantly lower; compared with the control group, the difference was not significant. Conclusion In epilepsy, the activity of GAD and GABA-T in epileptic neurons increased.