时间药理学是一门以时间生物学为基础发展起来的较新学科,它主要研究药物作用的时间节律性和药物对生物节律的影响,并对临床治疗选择最佳的用药时间,从而为达到理想的治疗目的提供科学依据。本文就其概念及其实际应用作一介绍。一、时间治疗学的基本概念把时间生物学的原理应用于药物治疗中,以获得最适的疗效和最小的副作用,并确定新的药效,这就是时间治疗的目的,时间药理学的进展,特别是药物作用和代谢时间节律的深入研究,为提高药物疗效和降低毒副反应提供了新的手段。长期以来,人们都是在保证发挥药物治疗作用的前提下,采用控制剂量的办法,将全天剂量根据药物在体内吸收和排泄的情况,以均分法给药,使毒副作用控制在尽可能的低水平上。现在人们可以根据药物疗 Time pharmacology is a relatively new discipline based on time biology. It mainly studies the time rhythm of drug action and the influence of drugs on the biological rhythm, and selects the best time for clinical treatment, so as to achieve The ideal therapeutic goal provides the scientific basis. This article gives an introduction to its concept and its practical application. First, the basic concept of chronotherapeutics applies the principles of chronobiology to drug therapy to obtain the most appropriate curative effect and minimal side effects, and to determine new drug efficacy. This is the purpose of chronotherapy, the development of chronopharmacology. In particular, the in-depth study of drug action and metabolic rhythm of metabolism provides new means for improving drug efficacy and reducing toxic and side effects. For a long time, people have been ensuring that drug therapy has been used. In this way, dose control measures are used to apply the dose throughout the day according to the absorption and excretion of drugs in the body. The low level. Now people can be based on medications