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有关人体衰老的分子损害学说,作为损害因子在人体内产生的自由基最引人关注。体内自由基主要来源于分子氧,其还原产生的自由基有超氧阴离子,过氧化氢及羟自由基等。它们在体内引发一系列脂质过氧化反应,最终产物为丙二醛(MDA)。氧自由基在体内又受到抗氧化酶如SOD、CAT及谷胱甘肽过氧化酶的抑制。因此,抗氧化酶活性及MDA水平预期会随年龄增长而发生改变。本文测定了不同年龄段的健康人群血中SOD、CAT及MDA的水平,以评价年龄对它们的影响。
The molecular damage theory of human aging, as a damaging factor in the body produce the most concern of free radicals. The main body of free radicals derived from molecular oxygen, its reduction of free radicals generated superoxide anion, hydrogen peroxide and hydroxyl radicals. They initiate a series of lipid peroxidations in the body, the end product being malondialdehyde (MDA). Oxygen free radicals in the body by the antioxidant enzymes such as SOD, CAT and glutathione peroxidase inhibition. Therefore, antioxidant enzyme activity and MDA levels are expected to change with age. This article measured the blood levels of SOD, CAT and MDA in healthy people of different ages to evaluate the impact of age on them.