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背景:冠状动脉钙化斑块是动脉粥样硬化斑块负荷的标记物,可预测未来发生心血管事件的风险。作者在一项随机化临床试验中研究了雌激素治疗与冠状动脉钙化之间的关系。方法:在对已行子宫切除的女性接受结合型马雌激素(0.625mg/d)与安慰剂进行比较的女性健康倡议试验的一项辅助性亚组研究中,对1064例
BACKGROUND: Coronary artery calcification plaques are markers of atherosclerotic plaque burden and predict the risk of future cardiovascular events. The authors studied the relationship between estrogen therapy and coronary artery calcification in a randomized clinical trial. METHODS: In an adjunct, subgroup study of women’s health initiative trials comparing women who had undergone hysterectomy with conjugated equine estrogens (0.625 mg / day) and placebo, 1064 patients