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目的探讨盐酸氨溴索联合沙丁胺醇氧气雾化吸入治疗老年慢性阻塞性肺病(COPD)的临床疗效。方法对我科收治的54例老年COPD患者,随机分为治疗组和对照组各27例,比较治疗后两组疗效及其肺功能变化。结果两组患者住院时间7～21d,总有效率治疗组明显高于对照组,差异有统计学意义(P<0.05)。治疗前两组FVC、FEV1%pred、FEV1%FVC比较,差异无统计学意义(P<0.05);治疗后两组以上指标均显著升高,且治疗组更明显,差异有统计学意义(P<0.05)。结论盐酸氨溴索联合沙丁胺醇氧气雾化吸入治疗COPD,两药协同作用,在化痰平喘的同时又明显改善通气功效,既缩短患者住院时间,加速康复,又减轻患者负担和痛苦。
Objective To investigate the clinical efficacy of ambroxol combined with salbutamol inhalation in the treatment of senile chronic obstructive pulmonary disease (COPD). Methods A total of 54 elderly COPD patients admitted to our department were randomly divided into treatment group and control group with 27 cases each. The curative effect and pulmonary function of the two groups were compared. Results The two groups of patients hospitalized for 7 ~ 21d, the total effective rate was significantly higher in the treatment group than in the control group, the difference was statistically significant (P <0.05). There were no significant differences in FVC, FEV1% pred and FEV1% FVC between the two groups before treatment (P <0.05); after treatment, the indexes in both groups were significantly increased, and the treatment group was more obvious, the difference was statistically significant (P <0.05). Conclusion Ambroxol Hydrochloride combined with salbutamol inhalation by oxygen inhalation treatment of COPD, synergistic effect of both drugs in the phlegm and asthma at the same time significantly improved ventilation efficacy, both to reduce hospital stay, speed recovery, and reduce the burden and suffering of patients.