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最近有报道证实在慢性心衰病人外周血管床,由胆碱能刺激引发的内皮细胞依赖性血管舒张功能减低。本试验的目的是确定在慢性心衰病人,血管紧张素转换酶抑制剂(ACEI)能否使外周血管内皮细胞依赖性血管舒张功能得到改善,并探索其作用机制。
Recently, it has been reported that peripheral blood vessel beds in patients with chronic heart failure have reduced endothelial cell-dependent vasodilation triggered by cholinergic stimulation. The purpose of this study was to determine if angiotensin converting enzyme inhibitors (ACEIs) can improve peripheral vascular endothelial cell-dependent vasodilatation in chronic heart failure patients and to explore their mechanisms of action.