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Objective:Evaluation of infertile couple indicated because of failure of conception for one year of unprotected intercourse, and indicated for the infertile couple because of failure of conception for 6 months of unprotected intercourse if the female partner is above 35 years. Initial male partner evaluation includes: 1) thorough reproductive history, and at least one semen analysis. If the initial male partner evaluation showed any abnormality, complete assessment needed.Initial assessment of the infertile male include; thorough reproductive history, and at least one semen examination. Endocrine assessment indicated for males with abnormal semen analysis. Post-ejaculatory urine analysis performed in males having <1 mL ejaculation volume, except in congenital bilateral absent vasa deferentia (CBAVD), and hypogonadism. Genetic testing for cystic fibrosis transmembrane conductance regulator (CFTR) mutations offered to male with CBAVD before IVF. Males with severe oligozoospermia and/or non-obstructive azoospermia are at risk of genetic abnormality, and must offered karyotype and Y-chromosome testing before IVF.