【摘 要】
：
Three new labdane diterpenoids, leojaponicone A(1), isoleojaponicone A(2) and methylisoleojaponicone A(3), were isolated from the herb of Leonurus japonicus. Th
【机 构】
：
College of Chemistry and Chemical Engineering, Anyang Normal University,Key Laboratory of Natural Me
【出 处】
：
Chinese Journal of Natural Medicines
论文部分内容阅读
Three new labdane diterpenoids, leojaponicone A(1), isoleojaponicone A(2) and methylisoleojaponicone A(3), were isolated from the herb of Leonurus japonicus. The chemical structures of these secondary metabolites were elucidated on the basis of 1 D and 2 D NMR, including HMQC, and HMBC spectroscopic techniques. All the new compounds were tested in vitro for their acetylcholinesterase and α-glucosidase inhibitory activity. Compounds 1-3 exhibited low inhibitory effects on α-glucosidase with respect to acarbose and exhibited high inhibitory effects on acetylcholinesterase with respect to huperzine A.
Three new labdane diterpenoids, leojaponicone A (1), isoleojaponicone A (2) and methylisoleojaponicone A (3), were isolated from the herb of Leonurus japonicus. The chemical structures of these secondary metabolites were elucidated on the basis of 1 D and 2 D All the new compounds were tested in vitro for their acetylcholinesterase and α-glucosidase inhibitory activity. Compounds 1-3 show low inhibitory effects on α-glucosidase with respect to acarbose and exhibited high inhibitory effects on acetylcholinesterase with respect to huperzine A.
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