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目的探讨布地奈德和沙丁胺醇溶液联合雾化吸入治疗毛细支气管炎临床疗效。方法将毛细支气管炎患儿96例随机分为治疗组(50例)和对照组(46例),2组均给予抗感染、祛痰、吸氧、镇静等全身用药综合治疗,治疗组加用布地奈德和沙丁胺醇溶液联合空气压缩泵雾化吸入;对照组给予地塞米松、a-糜蛋白酶雾化吸入,观察用药后2组患儿咳嗽、喘息、呼吸困难及肺部喘鸣音减轻、消退时间。结果治疗组的症状、体征改善优于对照组,病程缩短,差异有统计学意义(P<0.05)。总有效率治疗组明显高于对照组。结论布地奈德和沙丁胺醇溶液联合雾化吸入治疗毛细支气管炎,可明显改善症状及缩短病程,值得临床推广。
Objective To investigate the clinical efficacy of budesonide and salbutamol solution in combination with nebulization for the treatment of bronchiolitis. Methods Ninety-six children with bronchiolitis were randomly divided into treatment group (n = 50) and control group (n = 46). The two groups were given systemic anti-infective, expectorant, Budesonide and albuterol solution combined with air compression pump inhalation; control group was given dexamethasone, a-chymotrypsin inhalation, observed two groups of children coughing, wheezing, breathing difficulties and relieve lung wheezing, Fade away time. Results The improvement of symptoms and signs in treatment group was better than that in control group, and the course of disease was shortened. The difference was statistically significant (P <0.05). The total effective treatment group was significantly higher than the control group. Conclusion Budesonide and salbutamol inhalation combined with inhalation therapy for bronchiolitis, can significantly improve the symptoms and shorten the course of disease, is worth clinical promotion.