研究表明镉可引起高血压,钴可致钴性心肌病,汞能引起心肌营养不良性变化及动脉性低血压,铅则被认为是致粥样硬化性毒物。本文对广泛散布在生产及周围环境中的金属(铅、镉、钴、镍、铜)的毒害作用加以比较。我们认为金属阻断巯基而发生的氧化过程障碍是金属对心肌损伤作用之基础,是发病机理的一个因素。巯基供体——硫辛酰胺,还原的谷胱甘酞和金属同时注入动物体内,能减轻心肌的损害作用。 Studies have shown that cadmium can cause hypertension, cobalt can cause cobalt cardiomyopathy, mercury can cause changes in myocardial malnutrition and arterial hypotension, lead is considered to be atherogenic. This article compares the toxic effects of metals (lead, cadmium, cobalt, nickel, copper) widely dispersed in production and in the surrounding environment. We think that the metal barrier to oxidation of the thiol group is the basis of the effect of metal on myocardial injury and is a factor in the pathogenesis. Sulfhydryl donor - lipoamide, reduced glutathione and metal injected into animals at the same time, can reduce myocardial damage.