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目的 观察国产乌司他丁治疗急性胰腺炎的临床疗效及机制探讨。方法 2 5 6例证实急性胰腺炎的病人进入本研究 ,其中乌司他丁组 10 4例 ,对照奥曲肽组 15 2例 ,治疗 5d、7d、10d内分别观察症状、体征及实验室数据变化 ,用 χ2 检验进行统计处理。结果 乌司他丁组的临床症状、体征及实验室数据 ,在治疗前后的变化有显著性差异 (P <0 0 1) ,而治疗后的变化与奥曲肽组相比 ,差异无显著性 (P >0 0 5 ) ,但治疗组对血、尿淀粉酶的恢复时间较对照组更短 (P <0 0 5 )。结论 国产乌司他丁能明显改善急性胰腺炎病人的症状和体征 ,缩短疗程 ,对急性胰腺炎疗效较好 ,本组总有效率 10 0 % ,痊愈率 80 8% ,且副作用少见。
Objective To observe the clinical efficacy and mechanism of domestic ulinastatin in the treatment of acute pancreatitis. Methods Twenty-five patients with confirmed acute pancreatitis were enrolled in this study. Among them, 104 patients in ulinastatin group and 152 patients in control octreotide group were observed symptoms, signs and laboratory data on 5d, 7d and 10d after treatment. Χ2 test with statistical processing. Results The clinical symptoms, signs and laboratory data of the ulinastatin group were significantly different before and after treatment (P <0.01), but there was no significant difference between the octreotide group and the octreotide group (P > 0 0 5), but the treatment group of blood, urine amylase recovery time shorter than the control group (P <0 05). Conclusion Domestic ulinastatin can significantly improve the symptoms and signs of patients with acute pancreatitis, shorten the course of treatment, and has a good effect on acute pancreatitis. The total effective rate is 100%, the cure rate is 80.8%, and the side effects are rare.