链激酶(streptokinase,SK)为溶血性链球菌所合成的一种蛋白质,有溶解血栓,使血管再通的作用。从70年代开始,应用BK治疗肺栓塞等血栓性疾病,收到了较好的效果。近年来,国外已开始用于治疗急性心肌梗塞,与半剂量的组织型纤溶酶原激活剂(t-PA)联合使用治疗急性心肌梗塞,效果比单独使用t-PA好。但是,目前临床使用的SK是从溶血性链球菌中提取的,制备中仍残存细菌内毒素。80 Streptokinase (SK), a protein synthesized by hemolytic streptococcus, has the effect of dissolving blood clot and revascularization. From the 70’s, the application of BK treatment of thrombotic diseases such as pulmonary embolism, received good results. In recent years, foreign countries have begun to treat acute myocardial infarction, combined with half-dose of tissue-type plasminogen activator (t-PA) in the treatment of acute myocardial infarction, the effect is better than t-PA alone. However, the current clinical use of SK is extracted from hemolytic streptococcus, bacterial endotoxin remains in the preparation. 80