据认为,在癌症的始发过程中必需涉及到有关遗传的方面,许多致癌剂的代谢受膳食改变和膳食组成的影响。大部分有机的化学致癌剂也是致突变剂,而终致癌剂和致突变剂大体上是一致的。因此,致癌剂的代谢改变亦反应了其致突变性之改变,这已为细菌和果蝇中的研究所证实。在宿主中介试验(host-mediated assay)中,将一种指示微生物注射入小鼠的腹腔,并经口或非肠道给予受试化合物,经过一定时间之后,从腹腔取出这种指示微生物,检查其突变情况。虽然这种检测系统不能测定对小鼠的诱变作用,但可指明经小鼠代谢所产生的致突 It is believed that aspects of the heredity must be involved in the initiation of cancer, and the metabolism of many carcinogens is influenced by dietary changes and dietary composition. Most organic chemical carcinogens are also mutagens, and the final carcinogen and mutagen are roughly the same. Thus, metabolic changes in carcinogens also reflect changes in their mutagenicity, as evidenced by studies in bacteria and fruit flies. In a host-mediated assay, an indicator microorganism is injected into the abdominal cavity of a mouse and the test compound is administered orally or parenterally. After a certain period of time, the indicator microorganism is removed from the abdominal cavity and examined Its mutation situation. Although this test system can not determine the mutagenicity in mice, it can indicate the mutagenicity produced by mouse metabolism