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Objective:The aim of the study was to report a case with a giant phyllodes tumor of the left breast and discuss the diagnostic and management challenges.Methods:A 47-year-old female patient was admitted to our center (Department of General Surgery,the First Affiliated Hospital,Luzhou Medical College,China)due to a large left breast mass for about 2.5 years.Core tissue biopsy showed mixed epithelial-stromal proliferation suggestive of a phyllodes tumor.Left modified radical mastectomy with dissection of level I and level II lymph nodes was performed.Results:The pathologic findings of this procedure were consistent with borderline phyllodes tumor.The tumor measured 47.5cmx37.0cmx28.0cm and weighed 9.79 kg ex vivo.Conclusion:To our knowledge,this patient presented one of the biggest phyllodes tumors of breast in all cases reported in English-language publications so far.