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目的:分析无功能胰腺神经内分泌肿瘤(NF-pNENs)n 18F-FDG PET/CT影像特点，并分析其与病理和患者预后的关系。n 方法:回顾性纳入北京协和医院2011年1月至2017年7月间35例经病理证实的NF-pNENs患者[男17例，女18例，年龄(51±12)岁]，均行n 18F-FDG PET/CT显像。收集患者临床资料并随访，统计病灶数量，测量病灶最大径、SUVn max和肿瘤/肝SUVn max比值(T/L)等PET/CT图像参数。采用Mann-Whitney n U检验或Kruskal-Wallis秩和检验和Spearman秩相关分析数据。n 结果:35例患者(G1级6例，G2级21例，G3级8例)胰腺肿瘤最大径为3.0(2.1，6.1) cm，SUVn max为5.5(4.0，8.9)，PET/CT显像阳性32例。囊性1例，伴钙化2例，胰胆管扩张3例。10例出现转移，其中8例为肝转移。G1~G3级肿瘤T/L差异有统计学意义[1.23(0.60，2.00)、3.05(1.80，4.00)和3.90(1.90，7.60)；n H＝8.29，n P＝0.016]；而对应的SUVn max与肿瘤最大径差异均无统计学意义(n H值：4.34和3.37，n P值：0.114和0.186)。胰腺病灶T/L[2.78(1.48，3.94)]与细胞增殖核抗原Ki-67指数[8.0(3.0，20.0)]呈正相关(n rs＝0.631, n P<0.001)。有随访结果的27例中，20例完全缓解或病情稳定者胰腺原发病灶T/L明显低于7例进展或死亡患者[2.1(1.2，3.2)与7.5(3.4，13.4)；n z＝-3.37，n P＝0.001]。n 结论:18F-FDG PET/CT显像可较好地显示NF-pNENs原发灶及转移灶；原发灶T/L较SUVn max能更好地反映肿瘤增殖活性(基于Ki-67指数)，对预后判断有所帮助。n “,”Objective:To analyze n 18F-FDG PET/CT imaging features of non-functional pancreatic neuroendocrine neoplasms (NF-pNENs) and investigate its correlation with pathology and prognosis.n Methods:A total of 35 cases (17 males, 18 females; age (51±12) years) of pathologically confirmed NF-pNENs who underwent pretherapeutic n 18F-FDG PET/CT from January 2011 to July 2017 in Peking Union Medical College Hospital were retrospectively enrolled. Clinical data were collected and patients were followed up. PET/CT parameters including number and maximum diameter of lesions, SUVn max and pancreatic tumor-to-liver ratio (T/L) were measured. Mann-Whitney n U test and Kruskal-Wallis rank sum test, Spearman correlation analysis were used to analyze the data.n Results:Among the included 35 NF-pNENs patients (G1, n n=6; G2, n n=21; G3, n n=8) with maximum diameter of 3.0(2.1, 6.1) cm and SUVn max of 5.5(4.0, 8.9), 32 were positive in PET/CT. There were 1 patient with cystic, 2 with calcification and 3 with dilatation of pancreaticobiliary duct. Among 10 patients with metastases, 8 revealed multiple liver metastases. There was statistical difference of T/L among G1-G3 tumor (1.23(0.60, 2.00), 3.05(1.80, 4.00), 3.90(1.90, 7.60); n H=8.29, n P=0.016), but there were no statistical differences of SUVn max or maximum diameter among G1-G3 tumor (n H values: 4.34, 3.37, n P values: 0.114, 0.186). There was a significant correlation between T/L (2.78(1.48, 3.94)) and Ki-67 index (8.0(3.0, 20.0); n rs=0.631, n P<0.001). Among 27 patients with available follow-up results, T/L in patients with complete remission or stable disease (n n=20) was statistically lower than that in patients with progressive disease or death (n n=7) (2.1(1.2, 3.2) n vs 7.5(3.4, 13.4); n z=-3.37, n P=0.001).n Conclusions:18F-FDG PET/CT can detect primary and metastatic lesions of NF-pNENs. T/L can better reflect the proliferative activity based on Ki-67 index than SUVn max and it may be favorable on prognostic value.n