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目的 一氧化氮 (NitricOxide ,NO)在感染性休克中具有多种作用 ,但其对休克转归的影响目前仍不清楚。本研究用NO产生的前体物质L arg和其抑制剂NNLA从正反两个方面探讨其对内毒休克大鼠转归的影响。方法 实验大鼠分为生理盐水对照组 (NS)、内毒素 (10mg/kg ,ip)组 (ETX)、内毒素 +NNLA(4mg/kg ,ip)组、内毒素 +L arg(40mg/kg ,ip)组和内毒素 +NNLA +L arg组。上述处理后 ,测定大鼠不同时间的平均动脉压 (meanarterialpressure ,MAP)、血浆NO水平 (NO-2 /NO-3 )以及 2 4小时存活率。结果 内毒素休克大鼠 ,血浆NO-2 /NO-3 明显增加 ,同时MAP降低 ,NNLA虽可抑制NO产生 ,升高MAP ,但显著降低12小时和 2 4小时存活率 ;而L arg虽不能升高MAP ,但可使其维持稳定 ,且 2 4小时存活率明显提高。 结论 在本实验条件下 ,NO对内毒素休克可能有有利作用 ,抑制NO合成则对休克的转归不利。
Purpose Nitric Oxide (NO) plays a variety of roles in septic shock, but its effect on the outcome of shock is still unclear. In this study, L arg, a precursor of NO, and its inhibitor NNLA were used to investigate the effects of L arg and its inhibitor NNLA on the outcome of endotoxic shock rats in both pros and cons. Methods The experimental rats were randomly divided into four groups: NS group, ETX group, endotoxin + NNLA group (4mg / kg, ip), endotoxin + L arg group , ip) group and endotoxin + NNLA + L arg group. After the above treatment, mean arterial pressure (MAP), NO-2 / NO-3 level and 24-hour survival rate were measured at different time points. Results In endotoxic shock rats, plasma NO-2 / NO-3 increased significantly and MAP decreased at the same time. Although NNLA could inhibit the production of NO and increase MAP, it significantly decreased the survival rate of 12 hours and 24 hours, while L arg did not Increased MAP, but can make it stable, and 24 hours survival was significantly improved. Conclusions Under the experimental conditions, NO may have a beneficial effect on endotoxic shock and inhibit the synthesis of NO while adversely affecting the outcome of shock.