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应用免疫组化S－P方法，研究100例食管癌手术标本中nm23基因产物／NDPK的表达及其与淋巴结转移的关系。结果显示：食管癌原发灶中NDPK的阳性表达率随着食管癌浸润深度的进展逐渐下降，当肿瘤浸润全层时，阳性表达率明显低于浸润粘膜及粘膜下层者，两者差异有显著意义（P＜0．01）；无淋巴结转移者与有淋巴结转移者其阳性率差异具有显著性意义（P＜0．01）。
Immunohistochemical S-P method was used to study the expression of nm23/NDPK in 100 surgical specimens of esophageal cancer and its relationship with lymph node metastasis. The results showed that the positive expression rate of NDPK in primary lesions of esophageal cancer decreased with the progression of esophageal carcinoma invasion depth. When the tumor infiltrates the whole layer, the positive expression rate of NDPK was significantly lower than that of infiltrating mucosa and submucosa. There was a significant difference between them. Significance (P<0.01); There was a significant difference in the positive rate of lymph node metastasis and lymph node metastasis (P<0.01).