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目的:探讨子痫前期患者血脂及凝血指标变化及其临床价值。方法:选择2011年1月—2013年12月在我院分娩的妊娠妇女96例,分为正常妊娠组44例、轻度子痫前期组20例和重度子痫前期组32例。比较3组血清总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL),以及凝血酶原时间(PT)、活化的部分凝血酶原时间(APTT)和纤维蛋白原(FIB)等指标。结果:3组血脂及凝血指标存在显著差异(P<0.05)。其中,重度子痫前期组TC、TG及LDL水平,均显著高于正常妊娠组(P<0.05);HDL水平显著低于与正常妊娠组(P<0.05)。轻度子痫前期组TG水平,显著高于正常妊娠组(P<0.05);TC、HDL及LDL水平两组均差异不显著(P>0.05)。轻度子痫前期组、重度子痫前期组PT、APTT,均较正常妊娠组显著降低(P<0.05);FIB较正常妊娠组显著或非常显著升高(P<0.05,P<0.01)。结论:血脂及凝血指标变化对于子痫前期早期诊断和防治具有重要临床价值。
Objective: To investigate the changes of serum lipids and coagulation indexes in patients with preeclampsia and its clinical value. Methods: Ninety-six pregnant women delivered in our hospital from January 2011 to December 2013 were divided into normal pregnancy group (n = 44), mild preeclampsia group (n = 20) and severe preeclampsia group (n = 32). The levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL) and prothrombin time (PT), activated partial prothrombin time APTT) and fibrinogen (FIB) and other indicators. Results: There was significant difference between the three groups in blood lipid and coagulation index (P <0.05). Among them, TC, TG and LDL levels in severe preeclampsia group were significantly higher than those in normal pregnancy group (P <0.05); HDL levels were significantly lower than those in normal pregnancy group (P <0.05). The levels of TG in mild preeclampsia group were significantly higher than those in normal pregnancy group (P <0.05). The levels of TC, HDL and LDL in both groups were not significantly different (P> 0.05). The levels of PT and APTT in mild preeclampsia group and severe preeclampsia group were significantly lower than those in normal pregnancy group (P <0.05). FIB was significantly or significantly higher than that in normal pregnancy group (P <0.05, P <0.01). Conclusion: The changes of blood lipids and coagulation indexes have important clinical value in the diagnosis and prevention of early stage of preeclampsia.