细胞之间的粘附是机体免疫功能得以正常发挥和维持的基础,细胞表面细胞粘附分子-1(ＩＣＡＭ1)表达上调可出现于自身免疫病、内分泌疾病和某些肿瘤等多种疾病[1,2]。ＩＣＡＭ1除可表达于细胞表面外,尚可因缺少穿膜片段和胞浆区域,从细胞膜上脱落,以循环形式存在于机体血清和其它 The adhesion between cells is the basis for normal immune function to be maintained and maintained. The up-regulation of cell surface adhesion molecule-1 (ICAM1) may occur in many diseases such as autoimmune diseases, endocrine diseases and certain tumors [1 ,2]. In addition to being expressed on the cell surface, ICAM1 can still be shed from the cell membrane due to the lack of transmembrane segments and cytoplasmic regions, circulating in the body’s serum and other