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目的:观察半夏健胃滴丸对大鼠实验性胃溃疡的保护作用。方法:采用幽门结扎法复制大鼠胃溃疡模型,计算溃疡面积、溃疡指数并观察胃黏膜病理学变化。结果:半夏健胃滴丸组大鼠胃溃疡面积、溃疡指数降低,形态学观察显示胃黏膜坏死脱落程度较低,与模型组比较有显著差异(P<0.01)。结论:半夏健胃滴丸可减轻胃黏膜损伤程度,减少胃黏膜上皮细胞坏死,对胃黏膜有一定的保护作用。
Objective: To observe the protective effect of Banxia Jianwei drop pill on experimental gastric ulcer in rats. Methods: The rat gastric ulcer model was replicated by pylorus ligation and ulcer area, ulcer index and gastric mucosal pathological changes were observed. Results: The peptic ulcer area and ulcer index of Banxia Jianwei drop pills group were decreased. The morphological observation showed that the degree of gastric mucosal necrosis was lower than that of the model group (P <0.01). Conclusion: Banxiajianwei dripping pills can reduce the degree of gastric mucosal injury, reduce gastric mucosal epithelial cell necrosis, have a protective effect on gastric mucosa.