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1例43岁女性患者因肩周炎服用塞来昔布胶囊0.2g,2次/d,共服用2周.末次服药后2h上腹出现持续性钝痛,伴腹胀、恶心、呕吐.实验室检查示血清淀粉酶1 822 U/L,胰淀粉酶1 529 U/L,脂肪酶1 410 U/L,白细胞计数12.7×109/L,中性粒细胞0.74,淋巴细胞0.16.腹部超声检查和磁共振胰胆管造影示胰腺弥漫性增大、胰腺周围有液性渗出,诊断为急性胰腺炎.停用塞来昔布,禁食,给予营养支持和抑酶、抑酸、抗感染治疗13 d,患者腹痛、腹胀消失,实验室检查示淀粉酶86 U/L,胰淀粉酶48 U/L,脂肪酶55 U/L,白细胞计数7.2×109/L,中性粒细胞0.65,淋巴细胞0.32.胰腺CT示胰头、胰体和胰尾位于同一层面,形态及大小基本正常.“,”A 43-year old woman with scapulohumeral periarthritis received celecoxib 0.2 mg twice daily for 2 weeks.She developed upper abdominal persistent dull pain,distension,nausea and vomiting two hours after the last administration.Laboratory tests showed the following values:serum amylase 1 822 U/L,amylopsin 1 529 U/L,lipase 1 410 U/L,white blood cell count 12.7 × 109/L,neutrophils 0.74,and lymphocytes O.16.Abdominal ultrasound examination and magnetic resonance cholangiopancreatography showed a diffusely enlarged pancreas and fluid exudation around pancreas.The patient was diagnosed as acute pancreatitis.Celecoxib was withdrawn.Thirteen days after the therapy with jejunitas,nutritional supporting,enzyme inhibition,acid suppression,and anti-infection,her symptoms of abdominal pain and distensionwere disappeared.Laboratory tests showed the following values:serum amylase 86 U/L,amylopsin 48 U/L,lipase 55 U/L,white blood cell count 7.2 × 109/L,neutrophils 0.65,and lymphocytes 0.32.AbdominalCT showed caputpancreatis,corpora pancreatic,and pancreatic tail were located on the same level,the pancreatic shape and size were normal.