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目的:探讨HLA基因系统某些特定的等位基因,其同一基因在各种疾病的发生中均起重要作用的可能性。方法:实验组为用于不同研究目的的各类慢性疾病的DNA储存标本,共收集8种疾病,分别是:肝硬化、乙型肝炎表面抗原携带者、青光眼、鼻息肉、精神分裂症、白内障、艾滋病和慢性肾衰。每种疾病随机采取15份标本,共计12 0份标本;对照组标本取自献血体检健康者血样,共计80份。HLA- DR、DQ座位等位基因检测采用PCR SSP法。结果:HLA -DR、DQ座位各等位基因在“慢性疾病”组中不同疾病的分布构成比均无统计学显著差异;“慢性疾病”组与对照组比较,HLA- DR座位的各等位基因分布构成比无统计学显著差异,DQ座位的各等位基因分布构成比有统计学显著差异(P <0 .0 5 ) ;HLA- DQ9在“慢性疾病”组的检出率为14 . 5 8% ,在对照组的检出率为6 .2 5 % ,两组有统计学显著差异(P <0 0 5 )。结论:在HLA- DQ座位上可能存在与各类疾病发生有关的基因,HLA- DQ9可能在各类疾病的发生中有一定作用或其与一类有普遍致病意义的基因连锁。
Objective: To investigate the possibility that some specific alleles of HLA gene system play an important role in the occurrence of various diseases of the same gene. METHODS: The experimental group was a DNA stockpile of various chronic diseases used for different research purposes and collected a total of eight diseases: cirrhosis, carriers of hepatitis B surface antigen, glaucoma, nasal polyps, schizophrenia, cataracts AIDS and chronic renal failure. Fifteen specimens were randomly selected for each disease, for a total of 120 specimens. The control specimens were obtained from blood samples from healthy volunteers for blood donation, for a total of 80 samples. HLA-DR, DQ locus allele detection using PCR SSP method. Results: There was no significant difference in the distribution of different diseases in HLA-DR and DQ loci among the “chronic diseases” groups. Compared with the control group, the “HLA-DR” loci There was no statistically significant difference in the distribution of gene distribution between the two groups (P <0.05). The distribution of HLA-DQ9 in the “chronic disease” group was 14%. 58% in the control group, and 6.52% in the control group. There was a statistically significant difference between the two groups (P <0.05). CONCLUSION: HLA-DQ9 may be involved in various diseases in HLA-DQ loci. HLA-DQ9 may play a role in the occurrence of various diseases or it may be linked to a class of genes with general pathogenic significance.