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目的:通过对多囊卵巢综合征(PCOS)患者的临床表现及内分泌变化情况的观察,探讨内分泌水平变化与P-COS发病的相关性。方法:对2008年8月~2010年9月期间于深圳市西丽人民医院确诊为多囊卵巢综合征(PCOS)的100例患者联合使用克罗米芬及二甲双胍进行治疗,观察患者的性激素水平变化及血糖代谢情况。结果:PCOS患者治疗前后卵泡刺激素的分泌和空腹血糖变化不明显(P>0.05),而治疗前后空腹胰岛素、黄体生成素、睾酮、雄烯二酮的水平变化明显(P<0.05)。结论:理想的PCOS治疗方案为克罗米芬与二甲双胍联合治疗,在纠正高雄激素血症的同时改善胰岛素抵抗,值得临床推广应用。
OBJECTIVE: To investigate the correlation between the change of endocrine level and the incidence of P-COS by observing the clinical manifestations and endocrine changes of patients with polycystic ovary syndrome (PCOS). Methods: From August 2008 to September 2010 in Shenzhen Xili People’s Hospital diagnosed with polycystic ovary syndrome (PCOS) in 100 patients treated with clomiphene citrate and metformin were observed in patients with sex hormone levels and Blood glucose metabolism. Results: Before and after treatment, the secretion of follicle stimulating hormone and the fasting blood glucose did not change significantly (P> 0.05). The levels of fasting insulin, luteinizing hormone, testosterone and androstenedione changed significantly before and after treatment (P <0.05). Conclusion: The ideal PCOS regimen for the treatment of clomiphene citrate and metformin, in the correction of hyperandrogenism while improving insulin resistance, is worthy of clinical application.