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1974年有关文献曾报道了MLCu250是一种附有250mm和直径为0.3mm铜丝的塑料节育器。 1973年Tatum氏提出增加铜丝含量才能提高节育器可靠的避孕效果,从而导致发展了MLCu375节育器,包括375mm~2和直径为0.4mm的铜丝的节育器。长期使用含铜节育器后有时会遇到铜丝断裂问题,从而降低节育器的避孕效果。Luukkainen等提出使用银芯同时增加铜丝量可以避免降低避孕效果。一组临床医生使用两种带铜丝的节育器,一种有银芯,另一种没有银芯。在三年多期间,使用有银芯的节育器妇女比使用其他模式节育器妇女难于怀孕。 450名妇女试验了三种节育器,年龄在25和35
The 1974 literature reported that the MLCu250 is a plastic IUD with a 250 mm diameter and a 0.3 mm diameter copper wire. Tatum’s proposed increase in copper content in 1973 resulted in a more reliable contraceptive effect on the IUD, resulting in the development of the MLCu375 IUD, which includes 375mm2 and an IUD with 0.4mm diameter copper wire. Long-term use of copper-containing IUD sometimes encounter copper wire fracture problems, thereby reducing the IUD contraceptive effect. Luukkainen et al proposed the use of silver core while increasing the amount of copper wire to avoid contraceptive effectiveness. One group of clinicians used two types of IUDs with copper wires, one with a silver core and the other without a silver core. For more than three years, women using silver-core IUDs have been more difficult to conceive than women using other mode IUDs. 450 women tested three types of IUDs aged 25 and 35