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目的探讨来曲唑联合高纯度尿促性素治疗克罗米芬耐药的多囊卵巢综合征不孕的临床疗效。方法选取南平市人民医院2014年6月—2016年6月收治的克罗米芬耐药的多囊卵巢综合征不孕患者64例,随机分为对照组和观察组,各32例。对照组患者给予高纯度注射用尿促性素治疗,观察组患者给予来曲唑片联合高纯度注射用尿促性素治疗,两组患者均持续治疗2周。比较两组患者促排卵周期、雌二醇峰值、高纯度尿促性素剂量、子宫内膜厚度及卵泡成熟个数及治疗安全性。结果两组患者促排卵周期、雌二醇峰值、高纯度尿促性素剂量、子宫内膜厚度比较,差异无统计学意义(P>0.05);观察组患者直径10~14 mm卵泡数、直径≥15 mm卵泡数多于对照组(P<0.05)。两组患者治疗期间均未发生严重不良反应。结论曲唑联合高纯度尿促性素治疗克罗米芬耐药多囊卵巢综合征不孕患者的临床疗效确切,可有效促进卵泡成熟,且安全性好。
Objective To investigate the clinical efficacy of letrozole combined with high-purity urotensin in the treatment of clomiphene-resistant polycystic ovary syndrome infertility. Methods Sixty-four patients with clomiphene-resistant polycystic ovary syndrome who were admitted to Nanping Municipal People’s Hospital from June 2014 to June 2016 were randomly divided into control group and observation group, with 32 cases in each group. Patients in the control group were treated with high-purity urinary gonadotropin for injection. Patients in the observation group were treated with letrozole and high-purity urinary gonadotropin for injection. Patients in both groups were treated continuously for 2 weeks. Ovulation period, estradiol peak, high-purity urotensin dose, endometrial thickness, number of mature follicles and therapeutic safety were compared between the two groups. Results There was no significant difference in ovulation cycle, estradiol peak, high-purity urotensin dose and endometrial thickness between the two groups (P> 0.05). In the observation group, the number of follicles between 10 and 14 mm in diameter and diameter More than 15 mm follicles were found in the control group (P <0.05). Two groups of patients during the treatment did not occur serious adverse reactions. Conclusion The combination of pyrazole and high-purity urotensin in the treatment of clomiphene citrate resistant women with polycystic ovary syndrome is effective in promoting the follicle maturation with good safety.