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目的 :观察与分析慢性牙周炎患者采用中药三黄粉联合牙周宁治疗疗效及安全性。方法 :112例慢性牙周炎患者(共156颗患牙)按照随机抽签法分组为对照组与观察组,各56例(78颗)。对照组采用牙周宁口服治疗,6片/次,3次/d,连续用药4周;观察组于对照组治疗基础上加用中药三黄粉治疗。观察2组患者基线时及治疗后第2、4周出血指数(BI)和牙周袋深度(PD)及附着丧失(AL)值、临床疗效。结果 :治疗后第2、4周,2组患者BI、PD值较基线时明显下降;第2周时,观察组BI值为(0.89±0.09)、PD值为(2.59±0.05)明显低于对照组为BI值(1.13±0.10)、PD值(2.85±0.07);第4周时,观察组BI值为(0.15±0.04)与对照组为(0.19±0.03)比较无明显差异;观察组PD值为(1.86±0.05)明显低于对照组为(2.29±0.08)。治疗后第2、4周,对照组AL值无明显变化;治疗第2周时,观察组AL值与基线时、对照组比较无明显差异;治疗第4周时,观察组AL值低于基线时、对照组。观察组治疗有效率为91.03%(71/78)高于对照组83.33%(65/78);2组患者均未发生呕吐等不良反应。结论 :临床应用中西医结合治疗相比单纯西药治疗疗效更为显著,且无明显不良反应发生,值得进一步研究与分析。
Objective: To observe and analyze the efficacy and safety of Chinese traditional medicine Sanhuang powder combined with periodontal therapy in patients with chronic periodontitis. Methods: A total of 112 patients with chronic periodontitis (156 teeth) were randomly divided into control group and observation group (56 cases each). The control group was treated with periodontal oral treatment, 6 tablets / time, 3 times / d for 4 weeks. The observation group was treated with Sanhuang powder on the basis of the control group. The baseline and postoperative second and fourth week bleeding index (BI) and periodontal pocket depth (PD) and attachment loss (AL) values were observed in two groups of patients, the clinical efficacy. Results: After 2 and 4 weeks of treatment, the BI and PD values of the two groups were significantly lower than those of the baseline. At the second week, the BI value in the observation group was (0.89 ± 0.09) and the PD value was (2.59 ± 0.05) In the control group, the BI value was 1.13 ± 0.10 and the PD value was 2.85 ± 0.07. There was no significant difference in BI value between the observation group and the control group at the 4th week (0.15 ± 0.04) and (0.19 ± 0.03) The PD value was (1.86 ± 0.05) significantly lower than that of the control group (2.29 ± 0.08). At the 2nd and 4th week after treatment, there was no significant change in the AL value of the control group. At the second week of treatment, there was no significant difference in the AL value between the observation group and the control group. At the fourth week, the AL value in the observation group was lower than the baseline When the control group. The effective rate of observation group was 91.03% (71/78), which was higher than that of control group (83.33%, 65/78). No adverse reactions such as vomiting occurred in both groups. Conclusion: The clinical application of integrated traditional Chinese and Western medicine treatment compared with Western medicine treatment effect is more significant, and no obvious adverse reactions, it is worth further study and analysis.