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探讨了运动对高脂饮食诱导的肥胖Wistar大鼠胰岛素敏感性和甘油三酯脂酶mRNA、脂联素mRNA表达的影响。随机将大鼠分为3组：高脂饮食喂养加运动组（简称运动组）、高脂饮食喂养组（简称高脂组）和标准饮食对照组（简称对照组）。以RT-PGR法半定量测定脂肪组织部分甘油三酯脂酶mRNA、脂联素mRNA的表达同时检测血游离脂肪酸（FFA）、甘油三酯（TG）,并用稳态模式评估法（HOMA）评价胰岛素抵抗（IR）指数,实验结果显示,有氧运动具有改善高脂饮食诱导的脂质异常、提高胰岛素敏感性以及调节脂肪因子表达的作用。“,”This article has explored the effect of aerobic exercise on the insulin sensitivity,adipokines expression mRNA and adiponectin mRNA in high-fat diet fed Wistar rats.Rats were randomized into three groups： aerobic exercise group,fed with high fat diet group,and control group.The lipid adipokines expression mRNA and adiponectin mRNA and the free fatty acid（FFA）,triglycerid（TG） were detected by semi-quantity RT-PGR.Homeostasis model assessment was used to evaluate the insulin resistance（IR） index.The result indicates that aerobic exercise may reverse high-fat diet induced lipid abnormalities,improve insulin sensitivity,and regulate the expression of adiponectin＇s mRNA.