G-CSF是一种仅通过皮下注射,动员骨髓中的血管内皮祖细胞进入末梢血的造血细胞因子。在动物实验中,其通过介导血管新生减轻缺血,改善心肌梗死后的心功能。由于这种治疗简单易行,已经在临床应用,并已针对重度冠状动脉缺血和急性心肌梗死病例研究其有效性。但是,目前效果还不稳定。今后,期待通过基础实验明确其作用机制,并在此基础上制定高效和安全的治疗计划。 G-CSF is a hematopoietic cytokine that mobilizes vascular endothelial progenitor cells in bone marrow into peripheral blood by subcutaneous injection only. In animal experiments, it attenuates ischemia by mediating angiogenesis and improves cardiac function after myocardial infarction. Because of its simplicity and ease of treatment, it has been used clinically and its effectiveness has been investigated for severe coronary artery ischemia and acute myocardial infarction. However, the current effect is not stable. In the future, we hope that we can clarify the mechanism of action through basic experiments and, on this basis, formulate an effective and safe treatment plan.