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目的:试图通过药物促使短暂缺血后顿抑心肌朝着有利方面转化,促使心功能更快恢复。方法:采用犬颈总动脉—左旋支旁路模型,27只犬随机分为3组。结果:未用药组(n=9)旁路闭塞后心功能下降,再通后仍继续下降,生理盐水组(n=9)经旁路滴入后心功能指标无改善,而用依那普利拉[Enalaprilat,n=9,0.2 ml(0.01mg)/min]滴入5分钟,左心室压力下降最大速率(—dp/dt max)由161±53 kPa/s(1208±398 mmHg/s)升至175±75 kPa/s(1313±553 mmHg/s),滴入30分钟时达193±56 kPa/s(1448±420 mmHg/s)(P<0.05,与滴入即刻比较)。左心室压力上升最大速率(+dp/dt max)亦有明显升高。结论:依那普利拉似可加速顿抑心肌功能的恢复,可能具有心肌保护作用。
OBJECTIVE: To try to use drugs to promote transient myocardial infarction in the favorable aspects of conversion, to promote faster recovery of cardiac function. METHODS: Twenty-seven dogs were randomly divided into three groups using canine carotid artery-left circumflex artery bypass model. Results: In the untreated group (n = 9), the cardiac function decreased after bypass occlusion and continued to decline after reperfusion. The cardiac function index of the saline group (n = 9) The maximal rate of decrease in left ventricular pressure (-dp / dt max) was determined by 161 ± 53 kPa / s (1208 ± 398 mmHg / s) for 5 minutes with Enalaprilat (n = 9,0.2 ml (0.01 mg) ) To 175 ± 75 kPa / s (1313 ± 553 mmHg / s) and 193 ± 56 kPa / s (1448 ± 420 mmHg / s) at 30 minutes of instillation (P <0.05 vs. immediate infusion). The maximum rate of left ventricular pressure rise (+ dp / dt max) also increased significantly. Conclusion: Enalapril may be able to accelerate the recovery of myocardial function, which may have a protective effect on myocardium.