在毛囊的成长期,毛囊随着毛根鞘细胞的增殖变粗变大,深深陷入皮肤脂肪层,毛基质细胞增殖而使毛干伸长。由于粗毛的形成中促进毛根鞘细胞增殖是很重要的,故探讨了对含有毛根鞘细胞的毛囊上皮细胞增殖的促进物质。 经酶处理得到源于人头发的毛外毛根鞘细胞(hORS)以及源于大鼠体毛的毛囊上皮细胞(rHKC)。增殖促进作用的评价是在低钙的完全合成培养基中添加植物提取物等 During the growth period of the hair follicles, the hair follicles become thicker and larger with the proliferation of the hair root sheath cells, deeply into the fat layer of the skin, and the hair matrix cells proliferate and elongate the hair shafts. Since it is important to promote the proliferation of hair root sheath cells in the formation of coarse hair, the promotion substance for the proliferation of hair follicle epithelial cells containing hair root sheath cells was investigated. Enzymatic treatment resulted in human hair-derived hair root sheath cells (hORS) and hair follicle epithelial cells derived from rat body hair (rHKC). The evaluation of proliferation promotion is the addition of plant extracts, etc. in a low calcium fully synthetic medium