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应用免疫组织化学方法研究正常膀胱组织和膀胱癌组织中ｒａ５癌基因产物ｐ２１和Ｃ－ｍｙｃ蛋白的表达水平，结果发现５例正常膀胱组织中未见这两种蛋白表达。５８例膀胱癌中ｎ２１和ｃ－ｍｙｃ蛋白阳性表达率分别为６２．１％（３６／５８）和４３．１％（２５／５８）。阳性表达的ｃ－ｍｙｃｆｏｐ２１蛋白分别定位于膀胱癌细胞核内和细胞膜上，并且ｃ－ｍｙｃｆｏｐ２１蛋白阳性表达率与膀胱癌的病理分级、临床分期及患者术后生存期关系密切。提示ｐ２１和Ｃ－ｍｙｃ蛋白阳性表达参予了膀胱癌发生和发展过程，并且有可能成为膀胱癌预后的客观指标之一。
Immunohistochemistry was used to study the expression of ra2 oncogene products p21 and C-myc in normal bladder tissues and bladder cancer tissues. The results showed no expression of these two proteins in 5 normal bladder tissues. The positive expression rates of n21 and c-myc in 58 cases of bladder cancer were 62.1% (36/58) and 43.1% (25/58) respectively. The positive expression of c-mycfop21 protein localized in the nucleus and on the cell membrane respectively. The positive expression rate of c-mycfop21 protein was closely related to the pathological grade, clinical stage and survival time of bladder cancer. These results suggest that the positive expression of p21 and C-myc may participate in the development and progression of bladder cancer and may be one of the objective indicators of the prognosis of bladder cancer.