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青霉素是控制临床革兰氏阳性球菌感染有效的抗生素之一。随着我国医疗卫生事业的发展,临床对青霉素的需求量越来越大,尽管青霉素的产量近几年有了成倍的增长,但仍不能满足临床的需要。现在采用的青霉素生产工艺是要大量溶媒、不锈钢材及进口的离心机设备,使扩建新厂遇到困难,因此改革工艺解决新建厂的设备为临床提供质量好、数量多的青霉素十分必要。DBED沉淀法新工艺制备青霉素已由湖南医药工业研究所研制成,新工艺青霉素成品质量达到出厂要求,本文报告DGED沉淀法制备的青霉素(以下简称DBED青霉素)对临床过敏反应观察结果。
Penicillin is one of the effective antibiotics to control clinical Gram-positive cocci infections. With the development of medical and health undertakings in our country, the clinical demand for penicillin is getting larger and larger. Although the yield of penicillin has doubled in recent years, it still can not meet the clinical needs. Penicillin production process is now used to a large number of solvent, stainless steel and imported centrifuge equipment, so that the expansion of new plant encountered difficulties, so the reform process to solve the new plant equipment for the clinical provision of good quality, quantity of penicillin is necessary. DBED precipitation process for the preparation of new penicillin has been developed by the Hunan Institute of Pharmaceutical Industry, the new process of penicillin finished product quality to meet the factory requirements, this report DGED precipitation prepared penicillin (hereinafter referred to as DBED penicillin) clinical allergic reaction results.