所有生物均受昼夜及季节性节律的影响。“时辰生物学”这门学科虽早已建立,但昼夜节律对药物治疗的重要性,除皮质激素治疗外,很少被人注意。近15年的很多研究证明,很多药物体内处置的各个时相都可能受到昼夜节律的影响,这就形成药物动力学的一个新分支“时辰药物动力学(Chronopharmacokinetics)”。这门学科中常运用一些重要术语。例如,昼夜节律(Circadian rhythm)由若干外部因素[名“时标因子(Zeitgebers)”]将偏离的周期调正到24小时上来,谓之“同步化”。体内多种节律的周 All creatures are affected by circadian and seasonal rhythms. Although the discipline of “chrono biology” has long been established, the importance of circadian rhythms for drug therapy is seldom noticed except corticosteroid therapy. Numerous studies in the past 15 years have demonstrated that many phases of drug disposal in vivo are likely to be affected by circadian rhythms, leading to a new branch of pharmacokinetics called “Chronopharmacokinetics.” Some important terms are often used in this discipline. For example, circadian rhythm is adjusted by a number of external factors [known as “Zeitgebers”] to offset the period to 24 hours, which is called “synchronization.” In vivo rhythmic week