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目的了解哺乳期妇女服用200 mg碘油胶丸的有效保护期,并探索其尿碘变化的规律。方法在新疆阿克苏地区库车县牙哈镇的4个村选择109名近半年内未服用过碘油丸的19～36岁哺乳期妇女及其子女(20天～18个月婴幼儿),采用现场干预的方法,并于服药后的1、3、7、14、30、50、75、100 d分别采集尿样(5ml以上),同时采集婴幼儿实验组及对照组尿样,测定尿碘值。结果口服200 mg碘油胶丸后,哺乳期妇女及其婴幼儿尿碘中位数在干预后第一天达到峰值,为1 399.42μg/L、1 383.94μg/L,之后开始下降到干预后50 d的140.24μe/L、261.42μg/L;1～7 d维持高值段,7～30 d尿碘值下降较快,30 d以后尿碘缓慢下降;1～30 d干预组大于对照组,差异有统计学意义(P<0.01,非参数wilcoxon秩和检验),50d后两组间差异没有统计学意义(P>0.05)。结论哺乳期妇女口服200mg碘油胶丸的尿碘最长有效保护期不到50 d。
Objective To understand the effective protection period of lactating women taking 200 mg lipiodol capsules and to explore the changes of urinary iodine. Methods A total of 109 breast-feeding women aged 19-36 and their children (20 days to 18 months old) who had not taken iodized oil pills in the past six months were selected from 4 villages in Yaha Town, Kuqa County, Xinjiang Uygur Autonomous Region. On the 1st, 3rd, 7th, 14th, 30th, 50th, 75th and 100th day after treatment, urine samples (more than 5ml) were collected, urine samples of experimental group and control group were collected, urinary iodine value. Results After oral administration of 200 mg lipiodol capsules, the median urinary iodine of lactating women and their infants reached a peak at 1 399.42 μg / L and 1 383.94 μg / L on the first day after intervention, and then began to decline after intervention 140.24μe / L, and 261.42μg / L at 50d. The values of urinary iodine decreased rapidly from the first day to the seventh day, and the urinary iodine value decreased rapidly from 7 to 30 days. The urinary iodine slowly decreased after 30 days. (P <0.01, nonparametric wilcoxon rank sum test). There was no significant difference between the two groups after 50 days (P> 0.05). Conclusions The longest effective duration of protection of urinary iodine in lactating women orally with 200mg lipiodol capsules is less than 50 days.