论文部分内容阅读
目的了解新生儿维生素D水平,探讨维生素D与新生儿宫内感染的关系。方法选取2015年1-12月在该院产科定期体检、无重大疾病、无生殖道畸形孕妇分娩的新生儿,将有宫内感染高危因素的296例新生儿作为研究对象,根据感染结局分为宫内感染组36例和非宫内感染组260例,所有新生儿出生均进行25羟基维生素D[25-(OH)D]检测,了解不同胎龄新生儿维生素D水平,并比较两组25-(OH)D水平。结果新生儿维生素D缺乏发生率高达68.6%;胎龄越小,25-(OH)D水平越低,差异有统计学意义(P<0.05);宫内感染组维生素D缺乏的发生率高于非宫内感染组(83.3%vs.66.5%),差异有统计学意义(P<0.05);宫内感染组的25-(OH)D水平低于非宫内感染组(14.61±6.90)ng/ml vs.(17.58±7.41)ng/ml,差异有统计学意义(P<0.05)。结论新生儿普遍存在维生素D缺乏,胎龄越小的新生儿维生素D水平越低,维生素D水平低的新生儿更易发生宫内感染,故提高新生儿维生素D水平有望降低宫内感染的发生率。
Objective To understand the level of vitamin D in newborns and explore the relationship between vitamin D and neonatal intrauterine infection. Methods A total of 296 neonates with high risk factors for intrauterine infection were enrolled in this study. The newborns whose maternal obstetrics, gynecology, 36 cases of intrauterine infection and 260 cases of non-intrauterine infection, all newborns were 25 hydroxyvitamin D [25- (OH) D] test to understand the different gestational age neonates vitamin D levels, and compared two groups of 25 - (OH) D level. Results The incidence of neonatal vitamin D deficiency was as high as 68.6%. The smaller the gestational age, the lower the level of 25- (OH) D, the difference was statistically significant (P <0.05). The incidence of vitamin D deficiency in intrauterine infection was higher than The intrauterine infection group had lower level of 25- (OH) D than the non-intrauterine infection group (14.61 ± 6.90) ng / (83.3% vs.66.5%), the difference was statistically significant (P0.05) / ml vs. (17.58 ± 7.41) ng / ml, the difference was statistically significant (P <0.05). Conclusion Neonatal prevalence of vitamin D deficiency, the younger the gestational age the lower the level of vitamin D in newborns, neonatal low vitamin D levels are more likely to have intrauterine infection, so raising neonatal vitamin D levels are expected to reduce the incidence of intrauterine infection .