目的研究肝纤维化时细胞外基质代谢的血清学变化规律，以及抗肝纤维化治疗的重要性．方法实验对象２６９例分为３个观察组，即正常对照组（ｎ＝３０）ＣｈｉｌｄＡ组（ｎ＝１０３）及ＣｈｉｌｄＢ＋Ｃ组（ｎ＝１６６）．对每例观察对象作血清透明质酸（ＨＡ），Ⅲ型前胶原肽（ＰⅢＰ），Ⅳ型前胶原肽（ＰⅣＰ）．层粘蛋白（ＬＮ）水平测定和肝功能有关指标，如ＡＳＴ，ＡＬＴ，甘胆酸（ＣＧ）和吲哚氰绿（ＩＣＧ）潴留率等检测．结果和正常组比较，ＣｈｉｌｄＡ组及ＣｈｉｌｄＢ＋Ｃ组ＨＡ，ＰⅢＰ，ＰⅣＰ，ＬＮ以及ＡＬＴ，ＡＳＴ，ＣＧ，ＩＣＧ潴留率均值呈异常升高（Ｐ＜００１），但ＣｈｉｌｄＡ组及ＣｈｉｌｄＢ＋Ｃ组间无统计学差异．进一步研究还发现ＰⅢＰ，ＰⅣＰ，ＨＡ以及ＬＮ等血清浓度和ＣＧ，ＩＣＧ潴留率，ＡＳＴ，ＡＬＴ间呈密切正相关，经保肝、利胆等治疗，在血清ＡＳＴ，ＡＬＴ，ＣＧ及ＩＣＧ潴留率好转后ＨＡ，ＰⅢＰ，ＰⅣＰ，ＬＮ的血清水平也呈同向变化．结论部分肝硬变患者，肝纤维化的形成仍很活跃，积极有效的保肝，利胆，抗纤维化治疗十分必要 Objective To study the serological changes of extracellular matrix metabolism in liver fibrosis and the importance of anti-liver fibrosis therapy. Methods A total of 269 subjects were divided into three observation groups: Child A group (n = 103) and Child B + C group (n = 166). Serum hyaluronic acid (HA), type Ⅲ procollagen peptide (PⅢP) and type Ⅳ procollagen peptide (P Ⅳ P) were prepared for each observation group. Laminin (LN) levels and liver function indicators such as AST, ALT, glycocholic acid (CG) and indocyanine green (ICG) retention rate and other tests. Results Compared with the normal group, the average values ​​of HA, PⅢP, PⅣP, LN, ALT, AST, CG and ICG retention in ChildA and ChildB + C groups were significantly increased (P <001), but there was no statistical significance between ChildA group and ChildB + C group Differences Further study also found that PⅢP, PⅣP, HA and LN serum concentrations and CG, ICG retention, AST, ALT was closely related to the liver, gallbladder and other treatment, serum AST, ALT, CG and ICG retention rate The serum levels of HA, PⅢP, PⅣP and LN also changed in the same direction after the improvement. Conclusion In some patients with cirrhosis, the formation of hepatic fibrosis is still very active. It is very necessary to treat liver, gallbladder and fibrosis actively and effectively