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目的探讨COX-2基因多态性与食管癌易感性的关系。方法计算机检索PubMed和EMbase数据库,检索时间截至2011年1月1日,获取COX-2基因多态性与食管癌易感性关系的病例-对照研究。以食管癌组与对照组人群基因型分布的OR值及其95%CI为效应指标,在纯合子模型、显性模型和隐性模型中采用固定或随机效应模型进行Meta分析,并进行发表偏倚评估。统计分析采用Stata 11.0软件。结果共纳入5个病例-对照研究。Meta分析结果显示:在COX-2-765G>C多态性位点,显性模型中,与野生基因型GG相比,CC+GC合并的OR值(95%CI)为1.806(1.050,3.106),其余为阴性结果。在COX-2-1195G>A多态性位点中,纯合子模型、显性模型及隐性模型均为阳性结果。结论 COX-2基因多态性与食管癌易感性可能相关。
Objective To investigate the relationship between COX-2 gene polymorphism and susceptibility to esophageal cancer. Methods The PubMed and EMbase databases were searched by computer, and the case-control study was performed to retrieve the relationship between COX-2 gene polymorphism and susceptibility to esophageal cancer as of January 1, 2011. The OR of 95% CI and genotype distribution of esophageal cancer patients and control subjects were used as meta-analysis in homozygous, explicit and implicit models for meta-analysis and publication bias Evaluation. Statistical analysis using Stata 11.0 software. Results A total of five case-control studies were included. Meta-analysis showed that in the COX-2-765G> C polymorphism locus and dominant model, the OR of 95% CI of CC + GC was 1.806 (1.050, 3.106 ), The rest is negative. In COX-2-1195G> A polymorphic loci, homozygous model, dominant model and recessive model were positive results. Conclusion COX-2 gene polymorphism may be associated with susceptibility to esophageal cancer.