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目的对羊水干细胞(amniotic fluid-derived stem cells,AFSCs)的研究进展及在再生医学等领域的发展进行综述,探讨今后AFSCs研究的相关问题。方法查阅近年来AFSCs的相关文献,对AFSCs在再生医学领域研究的成果及其基础与临床研究展望进行综述。结果目前研究已表明AFSCs具有多向分化潜能,在组织工程或细胞替代治疗的研究中展现出广阔的应用前景。结论羊水取材简便,对母婴创伤小,无致瘤性,无伦理学方面的限制,使AFSCs极有希望成为再生医学、抗肿瘤等领域中理想的种子细胞,具有广泛研究价值。
Objective To summarize the research progress of amniotic fluid-derived stem cells (AFSCs) and their development in regenerative medicine and other fields, and to explore the related issues of AFSCs in the future. Methods To review the literature about AFSCs in recent years and summarize the results of AFSCs research in regenerative medicine and their basic and clinical research prospects. Results The current studies have shown that AFSCs have multidirectional differentiation potential, which has shown broad application prospects in tissue engineering or cell replacement therapy. Conclusions Amniotic fluid is easy to draw, with less trauma to maternal and infant, no tumorigenicity and no ethical restriction. Therefore, AFSCs are hopeful to be ideal seed cells in regenerative medicine and antitumor field and have extensive research value.