Four-wave-mixing (FWM) process is examined by using density matrix formalism in a periodically-driven atomic medium.Numerical result shows that FWM signals can be controlled by selecting different dynamic parameters of the probe field and strengths of the inner-dressing fields.It is also shown that the controllable FWM process is dominantly influenced by the evolution of atomic population difference and two-photon coherence.This dynamic and inner-dressing control of FWM is probably used for optimizing the optical nonlinear process and information processing.