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ANDS 与弥漫性肺微血管损伤有关,以内皮细胞渗透性的显著增加为特点,导致肺间质和肺泡的水肿。因为急性胰腺炎导致 ARDS 已屡见报告,作者考虑各种蛋白酶的释放可能是肺微血管损伤的因素,故对不同起因的 ANDS 病人和其它急症不同病期的血清酯酶(Lipase,LP),血清免疫活性胰蛋白酶(Immunoreactive trypsin,IRT),及几种胰蛋白酶抑制剂[血清胰蛋白酶抑制力(Trypsin inhibitory capa-city,TIC),α_1-抗胰蛋白酶(α_1-antitrypsin,α_1-AT),α_2-巨球蛋白(a_2-Macroglobulin,α_2-M),抗凝血酶Ⅲ(Antithrombin Ⅲ,AT-Ⅲ)]以及血管紧张索转换酶(ACE)间的关系进行了比较。共测定41例,均为呼吸监护病房的病人。其中
ANDS is associated with diffuse pulmonary microvascular damage characterized by a marked increase in endothelial cell permeability leading to edema of the pulmonary interstitium and alveoli. Because ARDS has been reported frequently in acute pancreatitis, the authors consider that the release of various proteases may be a contributing factor to pulmonary microvascular injury. Therefore, serum levels of esterase (Lipase, LP) and serum Immunoreactive trypsin (IRT) and several trypsin inhibitors [Trypsin inhibitory capa-city (TIC), α_1-antitrypsin (α_1-AT) Macroglobulin (α_2-M), antithrombin Ⅲ (AT-Ⅲ)] and angiotensin-converting enzyme (ACE) were compared. A total of 41 cases were measured, all respiratory care ward patients. among them