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目的探讨糖化低密度脂蛋白(G-LDL)水平与冠脉粥样硬化程度的关系。方法通过冠脉造影检查,选择糖尿病冠脉造影阴性(DM-NCHD)患者49例、糖尿病冠脉造影阳性(DM-CHD)患者50例及非糖尿病冠脉造影阴性(NC)患者50例。采用氯化硝基四氮唑蓝法检测DM-NCHD、DM-CHD及NC组的血清G-LDL水平。应用受试者工作特征曲线(ROC曲线)评价血清G-LDL的诊断效能和最佳诊断分界值。结果 DM-NCHD组G-LDL水平低于DM-CHD组(P<0.05),高于NC组(P<0.05)。血清G-LDL水平为50.45时,灵敏度为0.80,特异度为0.84。DM-CHD组G-LDL水平与冠脉粥样硬化程度(用Gensini评分表示)呈正相关(r=0.638,P=0.001)。结论DM-NCHD患者血清G-LDL水平明显低于DM-CHD患者,且G-LDL水平与冠脉粥样硬化程度呈正相关,G-LDL有望成为评价糖尿病患者冠脉粥样硬化风险的有效指标。
Objective To investigate the relationship between the level of glycosylated low density lipoprotein (G-LDL) and the degree of coronary atherosclerosis. Methods Forty-nine patients with diabetes mellitus (DM-NCHD), 50 patients with diabetes mellitus coronary angiography (DM-CHD) and 50 patients with non-diabetic coronary angiography (NC) underwent coronary angiography. Serum G-LDL levels in DM-NCHD, DM-CHD and NC groups were detected by nitrotetrazolium chloride blue method. The receiver operating characteristic curve (ROC curve) was used to evaluate the diagnostic efficacy and the best diagnostic cutoff for serum G-LDL. Results The level of G-LDL in DM-NCHD group was lower than that in DM-CHD group (P <0.05) and higher than that in NC group (P <0.05). Serum G-LDL level of 50.45, the sensitivity of 0.80, specificity of 0.84. The level of G-LDL in DM-CHD group was positively correlated with the degree of coronary atherosclerosis (Gensini score) (r = 0.638, P = 0.001). Conclusion The serum G-LDL level in patients with DM-NCHD is significantly lower than that in patients with DM-CHD, and the level of G-LDL is positively correlated with the degree of coronary atherosclerosis. G-LDL is expected to be an effective indicator to evaluate the risk of coronary atherosclerosis in diabetic patients .