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目的:应用高效液相色谱法测定复肾宁片中栀子苷的含量。方法:采用Shim-pack-C18柱(4.6 mm×150 mm,5μm),以乙腈-水(10∶90)为流动相,检测波长238 nm。结果:栀子苷线性范围为0.136～0.680μg,r=0.999 9。栀子苷的回收率分别为98.04%,RSD 0.46%。结论:该方法用于测定复肾宁片中栀子苷的含量,具有简便、准确、灵敏的特点,可作为该制剂质量控制的指标。
Objective: To determine the content of Geniposide in Fu Shen Ning Tablet by HPLC. Methods: Shim-pack-C18 column (4.6 mm × 150 mm, 5 μm) was used with acetonitrile-water (10:90) as the mobile phase and the detection wavelength was set at 238 nm. Results: Geniposide linear range of 0.136 ~ 0.680μg, r = 0.999 9. Geniposide recovery rates were 98.04%, RSD 0.46%. Conclusion: The method is suitable for the determination of geniposide in Fu Shen Ning Tablets. It is simple, accurate and sensitive and can be used as an indicator of quality control.