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细菌感染性疾病在我国患病新生儿中仍然占相当比例 ,此类疾病的早期诊断和及时治疗对提高诊疗水平、降低新生儿病死率有重要意义。近年来 ,降钙素原 (PCT)被认为是诊断全身性细菌感染性疾病的重要标志物。目前研究发现 ,细菌感染后血中PCT出现早于C反应蛋白 ,而且它具有较C反应蛋白和白细胞计数等临床常用指标更高的敏感性和特异性 ;另外 ,它与感染严重程度有较好的相关性 ,可用于评价疗效和估计预后。血清PCT检测简便快捷 ,便于临床应用 ,更重要的是 ,在新生儿期它不受母体PCT水平高低和窒息缺氧损伤引起的急性炎症反应的影响 ,仅与新生儿自身细菌感染严重程度有关 ,对新生儿疾病诊断有特殊意义。
Bacterial infectious diseases still account for a considerable proportion of newborns in China. The early diagnosis and timely treatment of such diseases are of great significance to improve the diagnosis and treatment and reduce the neonatal mortality. In recent years, procalcitonin (PCT) is considered to be an important marker for the diagnosis of systemic bacterial infections. The current study found that PCT in blood after bacterial infection was earlier than C-reactive protein, and it had higher sensitivity and specificity than the commonly used clinical indicators such as C-reactive protein and white blood cell count. In addition, it was better than the severity of infection The correlation can be used to evaluate the efficacy and prognosis. Serum PCT detection is simple and quick, easy to clinical application, more importantly, it is not affected in the neonatal period of the PCT level of the mother and the acute inflammatory reaction caused by asphyxiation and hypoxia injury, only with the neonatal bacterial infection severity, The diagnosis of neonatal diseases have special significance.