红霉素应用于临床已近40年,常见的不良反应已为临床医生所熟悉。现将近年来有关其特殊不良反应的报道综述如下。 1 肝脏毒性 1 例41岁患者在静滴红霉素时,出现全身瘙痒、荨麻疹,体温升至39.2℃。1d后出现恶心、呕吐、全身皮肤及巩膜黄染,后因严重肝脏毒性反应死亡。患者1年前曾静滴红霉素,出现过上述类似症状,既往无肝炎病史。尸检发现肝索解离,肝细胞呈弥漫性大片坏 Erythromycin has been used clinically for almost 40 years and common adverse reactions have become familiar to clinicians. Now in recent years, reports of its special side effects are summarized below. 1 liver toxicity 1 41-year-old patients with intravenous erythromycin, itching, urticaria, body temperature rose to 39.2 ℃. 1d after nausea, vomiting, systemic skin and scleral yellow dye, died of severe liver toxicity. Patients with intravenous erythromycin 1 year ago, there have been similar symptoms, no previous history of hepatitis. Autopsy revealed hepatic cord dissociation, liver cells were diffuse tracts of bad