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目的:分析放射学髋关节损害的AS患者骨强度指数、骨质疏松及骨折情况，探索该类患者骨强度变化的特点。方法:分析跟骨超声的骨强度指数与双能X线吸收法骨密度（DXA）值（全髋，g/cmn 2）之间的相关性，采用Pearson相关统计分析。纳入研究的339例AS患者依据Bath AS髋关节放射学指数（BASRI-hip）评分分组，采用n t检验、Mann-Whitney n U秩和检验及n χ2检验统计分析比较各组骨强度差异。Logistic回归分析骨强度低于同龄人的相关因素。n 结果:①跟骨超声骨强度指数与DXA（全髋，g/cmn 2）呈正相关（n r=0.553，n P<0.01）。②放射学髋关节损害组年龄27（23，37）岁低于无放射学髋关节损害组37（28，48）岁，差异有统计学意义（n Z=-5.986，n P0.05）。③在<50岁的AS患者中，与无放射学髋关节损害组相比，放射学髋关节损害组骨强度指数降低（78±18与84±16）、骨强度低于同龄人比率升高（41.0%与18.4%）、骨质疏松发生率升高（42.7%与28.8%）、脆性骨折发生率升高（3.7%与0%），差异均有统计学意义（n t=3.028，n P<0.01；n χ2=16.758，n P0.05）。④多因素分析结果显示放射学髋关节损害[n OR值（95%n CI）=1.912（1.05，3.48）]、年龄[n OR值（95%n CI）=0.94（0.911，0.97）]及BMI（kg/mn 2）[n OR值（95%n CI）=0.875（0.807，0.948）]与AS患者骨强度低于同龄人相关。n 结论:跟骨骨强度指数与DXA骨密度值呈正性强相关。放射学髋关节损害的AS骨强度降低，骨质疏松及脆性骨折发生风险升高。放射学髋关节损害、年龄及BMI与AS患者骨强度降低相关。“,”Objective:To analyze bone strength index, osteoporosis and fracture in ankylosing spondylitis (AS) patients with radiologic hip involvement and explore the characteristics of bone strength in these patients.Methods:According to bath ankylosing spondylitis radiology hip index (BASRI-hip) score, 339 AS patients were divided into two groups. The differences of bone strength in each group were analyzed by n t-test, Mann-Whitney n U test and n χ2 test. Logistic regression was used to analyze the risk factors of bone strength index. The correlation between quantitative ultrasound and dualenergy X-ray absorptiometry (DXA) (total hip, g/cmn 2) was analyzed. Pearson correlation analysis was used.n Results:①Bone strength index of quantitative ultrasound was positively correlated with bone mineral density of DXA (total hip, g/cmn 2), n r=0.553, n P<0.01. ② The age of 27(23, 37) years old in radiographic hip involvement was lower than 37(28, 48) years old in non-radiographic hip involvement, and the difference was statistically significant (n Z=-5.986, n P0.05).③ The radiographic hip involvement in AS patients whose ages were younger than 50, when compared with non-radiographic hip involvement patients, the bone strength index was lower (78±18n vs 84±16), while bone strength was lower than patients at the same age (41.0% n vs 18.4%), however, the incidences of osteoporosis (42.7% n vs 28.8%) and fragility fracture (3.7% n vs 0%) were significantly higher (n t=3.028, n P<0.01;n χ2=16.758, n P0.05). ④ Multivariate analysis showed that radiographic hip involvement [n OR (95% n CI)=1.912(1.05, 3.48)], age [n OR (95% n CI)=0.94(0.911, 0.97)] and body mass index (BMI) (kg/mn 2) [n OR (95% n CI) =0.875(0.807, 0.948)] were associated with lower bone strength.n Conclusion:There is positive correlation between the bone strength index of quantitative ultrasound and bone mineral density of DXA. AS patients with radiographic hip involvement are characterized by decreased bone strength and are more likely to develop osteoporosis and fragile fractures. The risk factors of low bone strength are radiographic hip involvement, age and BMI.