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目的通过检测细胞性凋亡抑制蛋白1(c-IAP1)和促凋亡蛋白第2个线粒体衍生的胱天蛋白酶激活剂(Smac)在儿童ALL中的表达,分析和探讨二者的关系及临床意义。方法采用病例对照研究,研究对象为48例ALL患儿。其中初治组23例,缓解组21例,复发组4例;对照组为12例骨髓象正常的非恶性血液病患儿。应用SP免疫组织化学方法分别检测各组患儿骨髓中c-IAP1、Smac蛋白表达情况。采用SPSS 12.0软件进行统计分析。结果 c-IAP1蛋白在初治组骨髓中阳性表达率为60.9%,缓解组阳性表达率为28.6%,复发组阳性表达率为75.0%,对照组阳性表达率为16.7%。Smac蛋白在初治组骨髓中阳性表达率为56.5%,缓解组阳性表达率为19.0%,复发组阳性表达率为75.0%,对照组阳性表达率为16.7%。c-IAP1、Smac蛋白在初治组ALL患儿骨髓中表达水平均分别高于缓解组(P<0.008)和对照组(P<0.008);初治组和复发组两因子比较,差异均无统计学意义(Pa>0.05);复发组中c-IAP1、Smac表达水平均高于对照组(Pa<0.008)。结论 c-IAP1、Smac可能参与了儿童ALL的发生与发展。
Objective To investigate the relationship between the expression of c-IAP1 and the second mitochondria-derived caspase-activating protein (Smac) in children with ALL, significance. Methods A case-control study was conducted in 48 children with ALL. Among them, 23 patients in the initial treatment group, 21 in the remission group and 4 in the recurrence group, and 12 in the control group were normal children with non-hematologic malignancies. SP immunohistochemistry was used to detect the expression of c-IAP1 and Smac in bone marrow of children in each group. Using SPSS 12.0 software for statistical analysis. Results The positive expression rate of c-IAP1 protein in primary bone marrow was 60.9%, in remission group was 28.6%, in recurrence group was 75.0%, in control group was 16.7%. The positive expression rate of Smac protein in primary treatment group was 56.5%, in remission group was 19.0%, in recurrence group was 75.0%, in control group was 16.7%. The expression of c-IAP1 and Smac in the bone marrow of ALL patients were significantly higher than that of the remission group (P <0.008) and the control group (P <0.008). There was no difference between the two groups Statistically significant (P> 0.05). The levels of c-IAP1 and Smac in recurrence group were higher than those in control group (Pa <0.008). Conclusion c-IAP1, Smac may be involved in the occurrence and development of childhood ALL.