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目的:探讨孕母HBsAg阳性患者及其新生儿注射乙型肝炎高效价免疫球蛋白(HBIG)前后对外周血中T细胞亚群的影响。方法:选取60例HBsAg阳性孕妇自愿在24、28、32周注射HBIG 200 U×3次,在注射HBIG前(自身对照组)及注射结束后检测外周血中T细胞亚群,另选取60例HBsAg阳性患者孕期没有注射HBIG的孕妇作为正常对照。在34周左右抽取静脉血检测外周血中T细胞亚群,比较正常对照组与注射组及注射前后外周血中T细胞亚群的变化。其新生儿出生即刻抽取外周血检测外周血中T细胞亚群及出生后立即注射HBIG 200 U,出生15 d注射HBIG 200 U,出生1个月时检测外周血中T细胞亚群,比较注射前后外周血中T细胞亚群的变化。结果:HBsAg阳性孕妇注射前后外周血中T细胞亚群比较,差异无统计学意义(P>0.05),注射组与正常对照组外周血中T细胞亚群的比较差异无统计学意义(P>0.05),其新生儿注射HBIG前后外周血中T细胞亚群差异无统计学意义(P>0.0.5)。结论:注射HBIG对孕母HBsAg阳性患者及其新生儿的外周血中T细胞亚群的水平无明显影响。
Objective: To investigate the effect of HBsAg positive pregnant women and their newborns on T cell subsets in peripheral blood before and after HBIG injection. Methods: Sixty pregnant women with positive HBsAg were injected with 200 U × 3 HBIGs voluntarily at 24, 28 and 32 weeks. T-cell subsets in peripheral blood were detected before injection of HBIG (self-control group) and after injection. Another 60 HBsAg-positive pregnant women who did not receive HBIG during pregnancy served as normal controls. Venous blood samples were collected at 34 weeks to detect T cell subsets in peripheral blood. The changes of T cell subsets in peripheral blood of normal control group, injection group and before and after injection were compared. Immediately after birth, T-cell subsets in peripheral blood were collected from peripheral blood and immediately after birth. HBIG was injected at 200 U after birth, and HBIG 200 U was injected 15 days after birth. T-cell subsets in peripheral blood were detected at 1 month after birth. Changes of T cell subsets in peripheral blood. Results: There was no significant difference in T cell subsets in peripheral blood between HBsAg positive pregnant women before and after injection (P> 0.05), but there was no significant difference in T cell subsets between the injected group and the normal control group (P> 0.05). There was no significant difference in T lymphocyte subsets between the newborns before and after HBIG injection (P> 0.05). Conclusion: The injection of HBIG has no significant effect on the level of T cell subsets in peripheral blood of HBsAg positive pregnant women and their newborns.